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Investigation of ergosterol was stimulated by the realization that it can be converted into vitamin D. Only in the final stages of this work (1932) was the arrangement of the component rings of the nucleus clarified by results obtained by pyrolytic (heat-induced bond-breaking) dehydrogenation and X-ray crystallography. With the foundations of steroid chemistry firmly laid, the next decade saw the elucidation of the structures of most of the physiologically potent steroid hormones of the gonads and the adrenal cortex, . Added impetus was given to steroid research when American physician Philip S.
