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Although its effectiveness in enhancing physical performance is still unproved, the compound is likely used for its potential anabolic effect on the muscle growth, and also in combination with other products (androgens, erythropoietin, etc. The degree of similarity between the endogenous and the recombinant forms, the pulsatile secretion and marked interindividual variability makes detection of doping difficult. Two approaches proposed to overcome this problem are: the indirect method, which measures a combination of several factors in the biological cascade affected by administration of GH; and the direct method, which measures the difference between the circulating and the recombinant (represented by the unique 22 kD molecule) forms of GH. This article gives an overview of what is presently known about hGH in relation to sport. The available methods of detection are also evaluated. Review of the literature on GH in relation to exercise, and its adverse effects and methods of detection when used for doping. The main effects of exercise on hGH production and the use and effects of rhGH in athletes are discussed. Difficulties encountered by laboratories to prove misuse of this substance by both indirect and direct analyses are emphasised. The direct method currently seems to have the best reliability, even though the time window of detection is too short. The effect of exercise on hGH and its short half?life are still presenting difficulties during doping analysis. To date the most promising method appears to be the direct approach utilising immunoassays. The human growth hormone (hGH) is a naturally occurring peptide hormone secreted by the pituitary gland. In the late 1980s, recombinant hGH (rhGH) was developed through genetic engineering and has been used with good results in the treatment of patients with hGH deficiency’allowing bone growth and impacting on the patient’s final stature. This form of hGH has a sequence identical to the naturally occurring 22 kDa hormone. Its misuse has been suspected in sport because of its anabolic properties. Athletes and bodybuilders claim that hGH increases lean body mass and decreases the fat mass. The use of hGH in sport today is not only based on its anabolic properties, but also on its effect on carbohydrate and fat metabolism. International federations and the International Olympic Committee have had hGH on the list of forbidden compounds since 1989, when it became obvious that the development of biotechnology products based on the recombination of DNA made hGH much more easily available on the regular and black markets. 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